Issue 17, 2021

Effects of soy isoflavone supplementation on patients with diabetic nephropathy: a systematic review and meta-analysis of randomized controlled trials

Abstract

Diabetic nephropathy (DN) is a microvascular complication that is becoming a worldwide public health concern. The aim of this study was to assess the effects of dietary soy isoflavone intervention on renal function and metabolic syndrome markers in DN patients. Seven databases including Medline, the Cochrane Central Register of Controlled Trials, Science Direct, Web of Science, Embase, China National Knowledge Infrastructure, and WanFang were searched for controlled trials that assessed the effects of soy isoflavone treatment in DN patients. Finally, a total of 141 patients from 7 randomized controlled trials were included. The meta-analysis showed that dietary soy isoflavones significantly decreased 24-hour urine protein, C-reactive protein (CRP), blood urea nitrogen (BUN), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose (FBG) in DN patients. The standard mean difference was −2.58 (95% CI: −3.94, −1.22; P = 0.0002) for 24-hour urine protein, −0.67 (95% CI: −0.94, −0.41; P < 0.00001) for BUN, −6.16 (95% CI: −9.02, −3.31; P < 0.0001) for CRP, −0.58 (95% CI: −0.83, −0.33; P < 0.00001) for TC, −0.41 (95% CI: −0.66, −0.16; P < 0.00001) for TG, −0.68 (95% CI: −0.94, −0.42; P < 0.00001) for LDL-C, and −0.39 (95% CI: −0.68, −0.10; P = 0.008) for FBG. Therefore, soy isoflavones may ameliorate DN by significantly decreasing 24-hour urine protein, BUN, CRP, TC, TG, LDL-C, and FBG.

Graphical abstract: Effects of soy isoflavone supplementation on patients with diabetic nephropathy: a systematic review and meta-analysis of randomized controlled trials

Article information

Article type
Review Article
Submitted
16 Apr 2021
Accepted
16 Jun 2021
First published
16 Jun 2021

Food Funct., 2021,12, 7607-7618

Effects of soy isoflavone supplementation on patients with diabetic nephropathy: a systematic review and meta-analysis of randomized controlled trials

X. Wang, Q. Liang, X. Zeng, G. Huang, G. Xin, Y. Xu, S. Wang and D. Tang, Food Funct., 2021, 12, 7607 DOI: 10.1039/D1FO01175H

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