Issue 68, 2021

N-Heterocyclic carbenes meet toll-like receptors

Abstract

Combining the stability of the N-heterocyclic carbenes (NHCs) and broad-spectrum recognition of toll-like receptor (TLR) proteins, we report new electrochemical biosensors for bacteria detection. Instead of traditional thiol–gold chemistry, newly synthesized NHCs are employed as the linker molecules to immobilize TLR bio-recognition elements on gold electrodes. Our proof-of-concept methodology includes testing the fidelity of TLR-based electrochemical sensors with NHC linkers. The performance of the biosensors is demonstrated using whole-cell bacterial cultures.

Graphical abstract: N-Heterocyclic carbenes meet toll-like receptors

Supplementary files

Article information

Article type
Communication
Submitted
08 Jun 2021
Accepted
04 Aug 2021
First published
04 Aug 2021

Chem. Commun., 2021,57, 8421-8424

N-Heterocyclic carbenes meet toll-like receptors

I. Singh, D. S. Lee, S. Huang, H. Bhattacharjee, W. Xu, J. F. McLeod, C. M. Crudden and Z. She, Chem. Commun., 2021, 57, 8421 DOI: 10.1039/D1CC03030B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements