Site-selective D2O-mediated deuteration of diaryl alcohols via quantum dots photocatalysis

Xiao-Lei Nan; Yao Wang; Xu-Bing Li; Chen-Ho Tung; Li-Zhu Wu

doi:10.1039/D1CC02551A

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Site-selective D₂O-mediated deuteration of diaryl alcohols via quantum dots photocatalysis†

Xiao-Lei Nan,^ab Yao Wang,^ab Xu-Bing Li,

*^ab Chen-Ho Tung

^ab and Li-Zhu Wu

*^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Beijing 100190, People's Republic of China
E-mail: lixubing@mail.ipc.ac.cn, lzwu@mail.ipc.ac.cn

^b School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Abstract

Owing to the high synthetic value of deuteration in the pharmaceutical industry, we describe herein the conversion of a range of aromatic ketones to deuterium-labeled products in good to excellent yields. Efficient and site-selective deuteration of benzyl alcohols by D₂O with visible light irradiation of quantum dots (QDs), together with gram-scale synthesis and photocatalyst recycling experiments indicated the potential of the developed method in practical organic synthesis.

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Article information

DOI: https://doi.org/10.1039/D1CC02551A
Article type: Communication
Submitted: 14 May 2021
Accepted: 03 Jun 2021
First published: 03 Jun 2021

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Chem. Commun., 2021,57, 6768-6771

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Site-selective D₂O-mediated deuteration of diaryl alcohols via quantum dots photocatalysis

X. Nan, Y. Wang, X. Li, C. Tung and L. Wu, Chem. Commun., 2021, 57, 6768 DOI: 10.1039/D1CC02551A

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Chemical Communications