Issue 57, 2021
From the journal:

Chemical Communications

Imidazolium labelling permits the sensitive mass-spectrometric detection of N-glycosides directly from serum†

Yao-Yao Zhang,‡a   Mattia Ghirardello, ORCID logo ‡b   Ting Wang,a   Ai-Min Lu,c   Li Liu, ORCID logo a   Josef Voglmeir ORCID logo *a  and  M. Carmen Galan ORCID logo *b  

* Corresponding authors

a Glycomics and Glycan Bioengineering Research Center (GGBRC), College of Food Science and Technology, Nanjing Agricultural University, 1 Weigang, 210095 Nanjing, China
E-mail: josef.voglmeir@njau.edu.cn
Web: http://www.ggbrc.com

b School of Chemistry, University of Bristol, Cantock's Close, BS8 1TS Bristol, UK
E-mail: m.c.galan@bristol.ac.uk
Web: http://www.galanresearch.com

c College of Sciences, Nanjing Agricultural University, 1 Weigang, 210095 Nanjing, China

Abstract

A novel imidazolium derivative (GITag) shows superior ionisation and consequently allows increased mass spectrometric detection capabilities of oligosaccharides and N-glycans. Here we demonstrate that human serum samples can be directly labelled by GITag on a MALDI target plate, abrogating prevalently required sample pretreatment or clean-up steps.

Graphical abstract: Imidazolium labelling permits the sensitive mass-spectrometric detection of N-glycosides directly from serum

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Article information

DOI
https://doi.org/10.1039/D1CC02100A
Article type
Communication
Submitted
20 Apr 2021
Accepted
17 Jun 2021
First published
17 Jun 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 7003-7006

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Imidazolium labelling permits the sensitive mass-spectrometric detection of N-glycosides directly from serum

Y. Zhang, M. Ghirardello, T. Wang, A. Lu, L. Liu, J. Voglmeir and M. C. Galan, Chem. Commun., 2021, 57, 7003 DOI: 10.1039/D1CC02100A

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