Manganese dioxide nanozyme for reactive oxygen therapy of bacterial infection and wound healing

Li Liu; Cheng Wang; Yuting Li; Lin Qiu; Shuwen Zhou; Pengfei Cui; Pengju Jiang; Xinye Ni; Runhui Liu; Xuancheng Du; Jianhao Wang; Jiang Xia

doi:10.1039/D1BM00683E

Manganese dioxide nanozyme for reactive oxygen therapy of bacterial infection and wound healing†

Li Liu,‡^a Cheng Wang,

‡^a Yuting Li,^a Lin Qiu,^a Shuwen Zhou,^a Pengfei Cui,

^a Pengju Jiang,^a Xinye Ni,*^b Runhui Liu,

^c Xuancheng Du,^d Jianhao Wang

*^a and Jiang Xia

*^e

Author affiliations

* Corresponding authors

^a School of Pharmacy, Changzhou University, Changzhou, Jiangsu 213164, China
E-mail: minuswan@163.com

^b The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, P. R. China
E-mail: nxy@njmu.edu.cn

^c State Key Laboratory of Bioreactor Engineering, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China

^d Institute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan 250100, China

^e Department of Chemistry, the Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
E-mail: jiangxia@cuhk.edu.hk

Abstract

Reactive oxygen species (ROS) are the weapons of neutrophiles against bacterial pathogens, and also the central effectors in reactive oxygen therapy for skin and soft tissue infection. Nanozymes that spontaneously generate ROS under physiological conditions are new antibacterials that hold promise towards multidrug resistant pathogens. The clinical use of the nanozymes is however limited by their low biocompatibility and toxicity in vivo. Here, we develop an oleic acid (OA) nanoemulsion template method for the one-pot synthesis of OA-manganese dioxide (MnO₂) nanozyme. The OA-MnO₂ nanozyme showed high stability and biocompatibility under physiological conditions with marked oxidase-like activity. The ROS generated by the OA-MnO₂ nanozyme effectively kill the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli strains. Moreover, the OA-MnO₂ nanozyme shows promising abilities to prevent and destruct biofilm formation by Staphylococcus aureus, and result in superior in vivo antibacterial performance as compared to vancomycin. The reactive oxygen therapy based on OA-MnO₂ nanozyme cures the infected skin and promotes wound healing in mice, manifesting its potential use in skin and soft tissue infection.

Biomaterials Science

Manganese dioxide nanozyme for reactive oxygen therapy of bacterial infection and wound healing†

Abstract

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Manganese dioxide nanozyme for reactive oxygen therapy of bacterial infection and wound healing

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