Tumor microenvironment and NIR laser dual-responsive release of berberine 9-O-pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy

Peifang Du; Jianhua Yan; Shuo Long; Hongjie Xiong; Nachuan Wen; Shundong Cai; Yirong Wang; Dongming Peng; Zhenbao Liu; Yanfei Liu

doi:10.1039/D0TB00489H

Tumor microenvironment and NIR laser dual-responsive release of berberine 9-O-pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy†

Peifang Du,

^a Jianhua Yan,

^b Shuo Long,

^a Hongjie Xiong,

^b Nachuan Wen,

^a Shundong Cai,

^b Yirong Wang,

^a Dongming Peng,

^c Zhenbao Liu

*^bd and Yanfei Liu

*^a

Author affiliations

* Corresponding authors

^a Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan Province, P. R. China
E-mail: liuyf@csu.edu.cn
Fax: +86-731 88879616

^b Xiangya School of Pharmaceutical Sciences, Central South University, No. 172, Tongzipo Road, Changsha, Hunan Province, P. R. China
E-mail: zhenbaoliu@csu.edu.cn
Fax: +86-731 83992279

^c Department of Medicinal Chemistry, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan Province, P. R. China

^d Molecular Imaging Research Center of Central South University, Changsha 410008, Hunan, P. R. China

Abstract

A berberine 9-O-pyrazole alkyl derivative, a chemical compound (called B3) previously synthesized by our group, shows anti-cancer activity. However, B3 lacks targeting cytotoxicity to cancer cells, leading to obvious toxic side effects on normal cells. To solve this problem, here, we prepared a drug delivery system, namely, AS1411-GO/B3 for tumor targeting, in which nano-graphene oxide (GO) sheets were employed as the drug carrier, and the aptamer AS1411 was conjugated onto GO for tumor targeting. GO also had a photothermal effect, which helped the release of B3 from GO as well as the thermal cytotoxicity to cells. We found that the release of B3 could respond to acid conditions, indicating that the tumor intracellular environment could promote the release of B3, thus allowing it to perform chemotherapy effects. This system could also release B3 in response to photothermal heating, moreover, combined photothermal therapy and chemotherapy to improve the anticancer activity was achieved. This AS1411-GO/B3 platform with chemo-photothermal synergetic therapy provides a very promising treatment for tumors.

This article is part of the themed collections: Journal of Materials Chemistry B Lunar New Year collection 2021 and Journal of Materials Chemistry B HOT Papers

Journal of Materials Chemistry B

Tumor microenvironment and NIR laser dual-responsive release of berberine 9-O-pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy†

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Tumor microenvironment and NIR laser dual-responsive release of berberine 9-O-pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy

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