Issue 24, 2020
From the journal:

Journal of Materials Chemistry B

Recent progress of SERS optical nanosensors for miRNA analysis

Yudie Sun,ab   Lin Shi,a   Lan Mi,a   Ruiyan Guoa  and  Tao Li ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Science & Technology of China, Hefei, Anhui, China
E-mail: tlitao@ustc.edu.cn
Fax: +86-551-63601813

b School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui 243032, China

Abstract

This review focuses on emerging applications of surface-enhanced Raman spectroscopy (SERS) optical nanosensors for miRNA analysis, in which the key enhancement factors of the SERS signal, i.e. SERS-active substrates, SERS nanoprobes and nano-assembly strategy, are emphasized. This article includes many nanomaterials for miRNA analysis by the SERS technique. We summarize these reported nanomaterials mainly according to their function in the miRNA assay biosensor. We also briefly summarize the research progress of these nanomaterials in SERS detection of intracellular miRNA. Finally, we discussed the prospect and limitations of SERS nanosensors for analyzing miRNA.

Graphical abstract: Recent progress of SERS optical nanosensors for miRNA analysis

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Article information

DOI
https://doi.org/10.1039/D0TB00280A
Article type
Review Article
Submitted
31 Jan 2020
Accepted
27 Apr 2020
First published
29 Apr 2020

J. Mater. Chem. B, 2020,8, 5178-5183

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Recent progress of SERS optical nanosensors for miRNA analysis

Y. Sun, L. Shi, L. Mi, R. Guo and T. Li, J. Mater. Chem. B, 2020, 8, 5178 DOI: 10.1039/D0TB00280A

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