Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

Weiwei Zhao; Hua Wang; Haimang Wang; Ying Han; Zhibo Zheng; Xudong Liu; Bin Feng; Hongyu Zhang

doi:10.1039/D0NR08887K

Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis†

Weiwei Zhao,^a Hua Wang,^b Haimang Wang,^a Ying Han,^a Zhibo Zheng,^c Xudong Liu,^d Bin Feng*^e and Hongyu Zhang

*^a

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* Corresponding authors

^a State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
E-mail: zhanghyu@tsinghua.edu.cn

^b Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China

^c Department of International Medical Services, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

^d Medical Science Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

^e Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

Abstract

Visible light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement were constructed by supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles (bMSNs-AZO) and β-cyclodextrin-modified poly(2-methacryloyloxyethyl phosphorylcholine) (CD-PMPC). Visible light could effectively trigger azobenzene isomerization and thus induce drug release after passing through the dermal tissue. Additionally, the hydration layer formed by CD-PMPC on the surface of the nanoparticles played an important role in lubrication enhancement, which was beneficial for the treatment of osteoarthritis.

This article is part of the themed collection: Nanoscale 2022 Lunar New Year Collection

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DOI: https://doi.org/10.1039/D0NR08887K
Article type: Communication
Submitted: 16 Dec 2020
Accepted: 19 Feb 2021
First published: 20 Feb 2021

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Nanoscale, 2021,13, 6394-6399

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Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

W. Zhao, H. Wang, H. Wang, Y. Han, Z. Zheng, X. Liu, B. Feng and H. Zhang, Nanoscale, 2021, 13, 6394 DOI: 10.1039/D0NR08887K

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Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis†

Abstract

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Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

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