Advanced nanomaterials for hypoxia tumor therapy: challenges and solutions

Aravindkumar Sundaram; Ling Peng; Luxiao Chai; Zhongjian Xie; Joice Sophia Ponraj; Xiangjiang Wang; Guiqing Wang; Bin Zhang; Guohui Nie; Ni Xie; Manavalan Rajesh Kumar; Han Zhang

doi:10.1039/D0NR06271E

Advanced nanomaterials for hypoxia tumor therapy: challenges and solutions

Aravindkumar Sundaram,†^abc Ling Peng,†^b Luxiao Chai,^b Zhongjian Xie,*^d Joice Sophia Ponraj,*^ce Xiangjiang Wang,^a Guiqing Wang,*^a Bin Zhang,^b Guohui Nie,^b Ni Xie,*^b Manavalan Rajesh Kumar

^f and Han Zhang

*^b

Author affiliations

* Corresponding authors

^a Department of Orthopaedic Surgery, the Sixth Affiliated Hospital of Guangzhou Medical University, 511508 Qingyuan, Guangdong, China
E-mail: 1918635344@qq.com

^b Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Institute of Microscale Optoelectronics, and Otolaryngology Department and Biobank of the First Affiliated Hospital, Shenzhen Second People's Hospital, Health Science Center, Shenzhen University, 518060 Shenzhen, China
E-mail: xn100@szu.edu.cn, hzhang@szu.edu.cn

^c Centre for Advanced Materials, Integrated-Inter-Department of LiWET Communications, Aaivalayam-Dynamic Integrated Research Academy and Corporations (A-DIRAC), 641046 Coimbatore, India
E-mail: joice.ponraj@aaivalayam.com

^d Shenzhen International Institute for Biomedical Research, 518116 Shenzhen, Guangdong, China
E-mail: zjxie2011@163.com

^e Department of Micro and Nanofabrication, International Iberian Nanotechnology Laboratory (INL), 4715-330 Braga, Portugal

^f Institute of Natural Science and Mathematics, Ural Federal University, 620002 Yekaterinburg, Russia

Abstract

In recent years, nanomaterials and nanotechnology have emerged as vital factors in the medical field with a unique contribution to cancer medicine. Given the increasing number of cancer patients, it is necessarily required to develop innovative strategies and therapeutic modalities to tackle hypoxia, which forms a hallmark and great barrier in treating solid tumors. The present review details the challenges in nanotechnology-based hypoxia, targeting the strategies and solutions for better therapeutic performances. The interaction between hypoxia and tumor is firstly introduced. Then, we review the recently developed engineered nanomaterials towards multimodal hypoxia tumor therapies, including chemotherapy, radiotherapy, and sonodynamic treatment. In the next part, we summarize the nanotechnology-based strategies for overcoming hypoxia problems. Finally, current challenges and future directions are proposed for successfully overcoming the hypoxia tumor problems.

This article is part of the themed collections: Nanoscale 2021 Emerging Investigators and Recent Review Articles

Nanoscale

Advanced nanomaterials for hypoxia tumor therapy: challenges and solutions

Abstract

Article information

Download Citation

Permissions

Advanced nanomaterials for hypoxia tumor therapy: challenges and solutions

Social activity

Search articles by author

Spotlight

Advertisements