Issue 16, 2020
From the journal:

Nanoscale

The essential role of osteoclast-derived exosomes in magnetic nanoparticle-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in an osteoporosis model†

Yue Zhu,a   Zhiyu Li,a   Yujia Zhang,a   Fang Lan, ORCID logo a   Jing He*a  and  Yao Wu ORCID logo *a  

* Corresponding authors

a National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064, P.R. China
E-mail: jinghe30@scu.edu.cn, wuyao@scu.edu.cn

Abstract

Magnetic hydroxyapatite (MHA) scaffolds promoted osteoblast proliferation in a model of osteoporosis through altering the osteoclast-derived exosomal cargo and decreasing the efficiency of exosome uptake by osteoblasts. Noticeably, certain proteins including ubiquitin, ATP and reactive oxygen species decreased in the osteoclast-derived exosomal cargo with MHA stimulation, while Rho kinase increased.

Graphical abstract: The essential role of osteoclast-derived exosomes in magnetic nanoparticle-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in an osteoporosis model

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Article information

DOI
https://doi.org/10.1039/D0NR00867B
Article type
Communication
Submitted
31 Jan 2020
Accepted
02 Mar 2020
First published
11 Mar 2020

Nanoscale, 2020,12, 8720-8726

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The essential role of osteoclast-derived exosomes in magnetic nanoparticle-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in an osteoporosis model

Y. Zhu, Z. Li, Y. Zhang, F. Lan, J. He and Y. Wu, Nanoscale, 2020, 12, 8720 DOI: 10.1039/D0NR00867B

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