Issue 6, 2020
From the journal:

Food & Function

Self-assembled composite nanoparticles based on zein as delivery vehicles of curcumin: role of chondroitin sulfate†

Chengzhen Liu,a   Yongkai Yuan,a   Mengjie Ma,b   Shuaizhong Zhang,a   Shuhui Wang,c   Hao Li,a   Ying Xu ORCID logo *a  and  Dongfeng Wanga  

* Corresponding authors

a College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province, People's Republic of China
E-mail: xuy@ouc.edu.cn
Tel: +860532-82031575

b School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, People's Republic of China

c Qingdao Municipal Center for Disease Control and Prevention & Qingdao Institute of Prevention Medicine, Shandong Province, People's Republic of China

Abstract

Composite nanoparticles composed of zein and chondroitin sulfate (CS) were self-assembled by the method of antisolvent precipitation to deliver curcumin (ZCCNPs). The structure of ZCCNPs changed from spheres to microaggregates with the increase of CS, involving hydrogen bonding and electrostatic and hydrophobic effects. The resistance of ZCCNPs to degeneration was improved by CS. The encapsulation efficiency of curcumin was enhanced by CS and showed the maximum (91.97%) when the mass ratio of zein-to-CS was 1 : 1 (ZCCNPs1:1). The crystallinity of curcumin changed to amorphous in ZCCNPs1:1. ZCCNPs1:1 exhibited great stability at pH 3.0–8.0, and it showed excellent thermostability at 35, 55, and 80 °C respectively for 120 min when the pH was 4.0 or 6.0. Meanwhile, it showed great storage stability at 4 and 22 °C respectively for 30 days. The retention rate of curcumin in ZCCNPs1:1 was higher than 65% within 8 days. The presence of CS improved the antiproliferative activity of curcumin-loaded zein nanoparticles (Cur-ZNPs) to HCT116 cells. ZCCNPs1:1 exhibited higher bioaccessibility (42.36%) than Cur-ZNPs. In addition, ZCCNPs1:1 exhibited excellent biocompatibility evaluated using in vitro cytotoxicity assay on NCM460 cells. The studies indicate that the delivery system fabricated in our work would be efficient for improving the application of hydrophobic nutrients in functional foods.

Graphical abstract: Self-assembled composite nanoparticles based on zein as delivery vehicles of curcumin: role of chondroitin sulfate

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Article information

DOI
https://doi.org/10.1039/D0FO00964D
Article type
Paper
Submitted
14 Apr 2020
Accepted
20 May 2020
First published
29 May 2020

Food Funct., 2020,11, 5377-5388

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Self-assembled composite nanoparticles based on zein as delivery vehicles of curcumin: role of chondroitin sulfate

C. Liu, Y. Yuan, M. Ma, S. Zhang, S. Wang, H. Li, Y. Xu and D. Wang, Food Funct., 2020, 11, 5377 DOI: 10.1039/D0FO00964D

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