Issue 39, 2020
From the journal:

Dalton Transactions

Concanavalin A targeting N-linked glycans in spike proteins influence viral interactions†

Hara Jang,a   Dong-Heon Lee,a   Hyun Goo Kangb  and  Seung Jae Lee ORCID logo *ac  

* Corresponding authors

a Department of Chemistry, Jeonbuk National University, Jeonju 54896, Republic of Korea
E-mail: slee026@jbnu.ac.kr

b Department of Neurology and Biomedical Research Institute, Jeonbuk National University, Jeonju 54896, Republic of Korea

c Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54896, Republic of Korea

Abstract

Lectins, which exhibit viral-interaction abilities, have garnered attention in the current pandemic era as potential neutralizing agents and vaccine candidates. Viral invasion through envelope proteins is modulated by N-linked glycosylation in the spike (S) protein. This study demonstrates the biophysical aspects between lectins and high-mannose and -galactose N-glycans to provide insights into binding events.

Graphical abstract: Concanavalin A targeting N-linked glycans in spike proteins influence viral interactions

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Article information

DOI
https://doi.org/10.1039/D0DT02932G
Article type
Communication
Submitted
21 Aug 2020
Accepted
14 Sep 2020
First published
01 Oct 2020

Dalton Trans., 2020,49, 13538-13543

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Concanavalin A targeting N-linked glycans in spike proteins influence viral interactions

H. Jang, D. Lee, H. G. Kang and S. J. Lee, Dalton Trans., 2020, 49, 13538 DOI: 10.1039/D0DT02932G

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