Co-delivery of proteins and small molecule drugs for mitochondria-targeted combination therapy

Si Si Liew; Jia Zhou; Lin Li; Shao Q. Yao

doi:10.1039/D0CC08020A

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Co-delivery of proteins and small molecule drugs for mitochondria-targeted combination therapy†

Si Si Liew,^a Jia Zhou,^b Lin Li

*^b and Shao Q. Yao

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore
E-mail: chmyaosq@nus.edu.sg

^b Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University, Nanjing 211816, P. R. China
E-mail: iamlli@njtech.edu.cn

Abstract

Herein, we report the first use of gluthathione (GSH)-responsive nanogel-based carriers for mitochondria-targeted delivery of functional proteins and antibodies. We further demonstrated the successful co-encapsulation of a protein and small molecule (RNase A/Doxorubicin) in dual-cargo nanocapsules for mitochondria-targeted combination therapy.

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Article information

DOI: https://doi.org/10.1039/D0CC08020A
Article type: Communication
Submitted: 10 Dec 2020
Accepted: 18 Feb 2021
First published: 18 Feb 2021

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Chem. Commun., 2021,57, 3215-3218

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Co-delivery of proteins and small molecule drugs for mitochondria-targeted combination therapy

S. S. Liew, J. Zhou, L. Li and S. Q. Yao, Chem. Commun., 2021, 57, 3215 DOI: 10.1039/D0CC08020A

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Chemical Communications

Co-delivery of proteins and small molecule drugs for mitochondria-targeted combination therapy†

Abstract

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Co-delivery of proteins and small molecule drugs for mitochondria-targeted combination therapy

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