Issue 9, 2021
From the journal:

Chemical Communications

The design of cyclometalated iridium(iii)–metformin complexes for hypoxic cancer treatment†

Jing Yang,‡ab   Hao-Ji Fang,‡a   Qian Cao ORCID logo *a  and  Zong-Wan Mao ORCID logo *a  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
E-mail: caoqian3@mail.sysu.edu.cn, cesmzw@mail.sysu.edu.cn

b Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China

Abstract

Modulating the hypoxic microenvironment is the priority for tumor treatment. Cytometalated iridium(III)–metformin conjugates were synthesized for treating hypoxic cancer cells for the first time, which alleviate hypoxia via mitochondria respiration inhibition, thus displaying 10-fold higher cytotoxicity, emerging anti-metastasis and anti-inflammatory activities than a metformin-free Ir(III) complex and cisplatin against hypoxic cancer cells.

Graphical abstract: The design of cyclometalated iridium(iii)–metformin complexes for hypoxic cancer treatment

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Article information

DOI
https://doi.org/10.1039/D0CC07104H
Article type
Communication
Submitted
27 Oct 2020
Accepted
04 Jan 2021
First published
05 Jan 2021

Chem. Commun., 2021,57, 1093-1096

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The design of cyclometalated iridium(III)–metformin complexes for hypoxic cancer treatment

J. Yang, H. Fang, Q. Cao and Z. Mao, Chem. Commun., 2021, 57, 1093 DOI: 10.1039/D0CC07104H

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