A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish

Zhenbo Guo; Mei Wang; Xueyan Li; Xu Jia; Xiaoli Wang; Pingzhu Zhang; Chao Wei; Xiaoliu Li

doi:10.1039/D0CC05330A

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A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish†

Zhenbo Guo,^ab Mei Wang,*^b Xueyan Li,^b Xu Jia,^ab Xiaoli Wang,^b Pingzhu Zhang,^ab Chao Wei

*^ab and Xiaoliu Li^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding 071002, China
E-mail: weichao@hbu.edu.cn

^b College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
E-mail: wangmarian@163.com

Abstract

A hepatocyte-targeting fluorescent N₂H₄ probe, GHP, was first designed and synthesized employing N-acetylgalactosamine (GalNAc) as the hepatocyte-targeting group and 3-nitrophthalimide as the recognition moiety. The probe can be used to selectively image N₂H₄ produced by the hydrolysis of isoniazid in HepG2 cells and the liver of zebrafish in situ.

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Article information

DOI: https://doi.org/10.1039/D0CC05330A
Article type: Communication
Submitted: 05 Aug 2020
Accepted: 19 Oct 2020
First published: 19 Oct 2020

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Chem. Commun., 2020,56, 14183-14186

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A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish

Z. Guo, M. Wang, X. Li, X. Jia, X. Wang, P. Zhang, C. Wei and X. Li, Chem. Commun., 2020, 56, 14183 DOI: 10.1039/D0CC05330A

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Chemical Communications

A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish†

Abstract

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A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish

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