Issue 85, 2020
From the journal:

Chemical Communications

A coassembled peptide hydrogel boosts the radiosensitization of cisplatin†

Qian Wang,a   Xiaoxue Hou,a   Jie Gao,a   Chunhua Ren, ORCID logo a   Qingxiang Guo,a   Huirong Fan,a   Jinjian Liu, ORCID logo *a   Wenxue Zhang*b  and  Jianfeng Liu ORCID logo *a  

* Corresponding authors

a Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, P. R. China
E-mail: liujianfeng@irm-cams.ac.cn

b Radiation Oncology Department, Tianjin Medical University General Hospital, Tianjin 300052, P. R. China
E-mail: wenxuezhang@tmu.edu.cn

Abstract

We constructed a novel supramolecular hydrogel by carrying out a coassembly of cisplatin and short naproxen-capped peptides. This procedure boosted the radiosensitization effect of cisplatin by increasing the number of Pt–DNA adducts, arresting the cell cycle, and inhibiting cyclooxygenase-2.

Graphical abstract: A coassembled peptide hydrogel boosts the radiosensitization of cisplatin

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Article information

DOI
https://doi.org/10.1039/D0CC05184E
Article type
Communication
Submitted
30 Jul 2020
Accepted
14 Sep 2020
First published
15 Sep 2020

Chem. Commun., 2020,56, 13017-13020

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A coassembled peptide hydrogel boosts the radiosensitization of cisplatin

Q. Wang, X. Hou, J. Gao, C. Ren, Q. Guo, H. Fan, J. Liu, W. Zhang and J. Liu, Chem. Commun., 2020, 56, 13017 DOI: 10.1039/D0CC05184E

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