Issue 77, 2020
From the journal:

Chemical Communications

Visible-light-induced triple catalysis for a ring-opening cyanation of cyclopropyl ketones†

Jing Liu,‡a   Xiao-Peng Liu,‡a   Hong Wu,a   Yi Wei,a   Fu-Dong Lu,a   Kai-Rui Guo,a   Ying Cheng*a  and  Wen-Jing Xiao ORCID logo *ab  

* Corresponding authors

a CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
E-mail: ycheng@mail.ccnu.edu.cn, wxiao@mail.ccnu.edu.cn

b State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China

Abstract

An unprecedented triple catalytic, general ring-opening cyanation reaction of cyclopropyl ketones for the construction of γ-cyanoketones is described. The key is to merge photoredox catalysis with Lewis acid catalysis and copper catalysis to enable the selective cleavage of the carbon–carbon bonds and the selective coupling of the generated radical and cyanide anion.

Graphical abstract: Visible-light-induced triple catalysis for a ring-opening cyanation of cyclopropyl ketones

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Article information

DOI
https://doi.org/10.1039/D0CC05167E
Article type
Communication
Submitted
29 Jul 2020
Accepted
17 Aug 2020
First published
19 Aug 2020

Chem. Commun., 2020,56, 11508-11511

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Visible-light-induced triple catalysis for a ring-opening cyanation of cyclopropyl ketones

J. Liu, X. Liu, H. Wu, Y. Wei, F. Lu, K. Guo, Y. Cheng and W. Xiao, Chem. Commun., 2020, 56, 11508 DOI: 10.1039/D0CC05167E

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