Issue 86, 2020

Small molecule induced toxic human-IAPP species characterized by NMR

Abstract

In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective, which is reflected in a strong interference with hIAPP aggregation while showing weaker interactions with human-calcitonin and amyloid-β1–40 in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.

Graphical abstract: Small molecule induced toxic human-IAPP species characterized by NMR

Supplementary files

Article information

Article type
Communication
Submitted
13 Jul 2020
Accepted
23 Sep 2020
First published
23 Sep 2020

Chem. Commun., 2020,56, 13129-13132

Small molecule induced toxic human-IAPP species characterized by NMR

S. J. Cox, D. C. Rodriguez Camargo, Y. Lee, R. C. A. Dubini, P. Rovó, M. I. Ivanova, V. Padmini, B. Reif and A. Ramamoorthy, Chem. Commun., 2020, 56, 13129 DOI: 10.1039/D0CC04803H

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