Deaminative carbonylative coupling of alkylamines with styrenes under transition-metal-free conditions

Fengqian Zhao; Chong-Liang Li; Xiao-Feng Wu

doi:10.1039/D0CC04062B

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Deaminative carbonylative coupling of alkylamines with styrenes under transition-metal-free conditions†

Fengqian Zhao,^a Chong-Liang Li^ab and Xiao-Feng Wu

*^ab

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* Corresponding authors

^a Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert-Einstein-Straβe 29a, 18059 Rostock, Germany
E-mail: xiao-feng.wu@catalysis.de

^b Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China

Abstract

A transition-metal-free deaminative carbonylation of alkylamines with styrenes has been developed. The reaction shows good functional group compatibility and various α,β-unsaturated ketones were obtained in moderate to good yields. The alkyl radical generated from Katritzky salts via base-promoted C–N bond cleavage is one of the key intermediates in this reaction.

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Article information

DOI: https://doi.org/10.1039/D0CC04062B
Article type: Communication
Submitted: 10 Jun 2020
Accepted: 07 Jul 2020
First published: 08 Jul 2020

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Chem. Commun., 2020,56, 9182-9185

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Deaminative carbonylative coupling of alkylamines with styrenes under transition-metal-free conditions

F. Zhao, C. Li and X. Wu, Chem. Commun., 2020, 56, 9182 DOI: 10.1039/D0CC04062B

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Chemical Communications

Deaminative carbonylative coupling of alkylamines with styrenes under transition-metal-free conditions†

Abstract

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Deaminative carbonylative coupling of alkylamines with styrenes under transition-metal-free conditions

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