Clustered nanobody–drug conjugates for targeted cancer therapy

Tiantian Wu; Manman Liu; Hai Huang; Yaping Sheng; Haihua Xiao; Yangzhong Liu

doi:10.1039/D0CC03396K

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Clustered nanobody–drug conjugates for targeted cancer therapy†

Tiantian Wu,‡^a Manman Liu,‡^a Hai Huang,

^a Yaping Sheng,^a Haihua Xiao^b and Yangzhong Liu

*^a

Author affiliations

* Corresponding authors

^a The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China
E-mail: liuyz@ustc.edu.cn

^b Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Abstract

A clustered Nb–drug conjugate (cNDC@PEG) was designed using anti-EGFR Nb to specifically deliver Pt(IV) prodrugs to tumors. cNDC@PEG efficiently targets EGFR positive tumor cells, and the clustered cNDC@PEG is more efficient in inhibiting tumor growth in vivo than the monomeric NDC. This work provides a novel strategy for the construction of a multi-valent NDC using dendrimers.

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Article information

DOI: https://doi.org/10.1039/D0CC03396K
Article type: Communication
Submitted: 11 May 2020
Accepted: 19 Jun 2020
First published: 16 Jul 2020

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Chem. Commun., 2020,56, 9344-9347

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Clustered nanobody–drug conjugates for targeted cancer therapy

T. Wu, M. Liu, H. Huang, Y. Sheng, H. Xiao and Y. Liu, Chem. Commun., 2020, 56, 9344 DOI: 10.1039/D0CC03396K

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Chemical Communications

Clustered nanobody–drug conjugates for targeted cancer therapy†

Abstract

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Clustered nanobody–drug conjugates for targeted cancer therapy

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