Issue 41, 2020
From the journal:

Chemical Communications

Rhodium(iii)-catalyzed synthesis of spirocyclic isoindole N-oxides and isobenzofuranones via C–H activation and spiroannulation†

Xi Han,‡a   Lingheng Kong, ORCID logo ‡a   Jiami Fenga  and  Xingwei Li*a  

* Corresponding authors

a Key Laboratory of Applied Surface and Colloid Chemistry of MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
E-mail: lixw@snnu.edu.cn

Abstract

Rhodium(III)-catalyzed mild and oxidative [4+1] spiroannulation has been realized via C–H activation of oximes and benzoic acids with 1-diazonaphthelen-2(1H)-ones as coupling reagents. This transformation integrates C–H activation and dearomatization and provides a direct approach to spirocyclic isoindole N-oxides and isobenzofuranones with functional group tolerance.

Graphical abstract: Rhodium(iii)-catalyzed synthesis of spirocyclic isoindole N-oxides and isobenzofuranones via C–H activation and spiroannulation

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Article information

DOI
https://doi.org/10.1039/D0CC00830C
Article type
Communication
Submitted
01 Feb 2020
Accepted
02 Apr 2020
First published
03 Apr 2020

Chem. Commun., 2020,56, 5528-5531

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Rhodium(III)-catalyzed synthesis of spirocyclic isoindole N-oxides and isobenzofuranones via C–H activation and spiroannulation

X. Han, L. Kong, J. Feng and X. Li, Chem. Commun., 2020, 56, 5528 DOI: 10.1039/D0CC00830C

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