Issue 17, 2020
From the journal:

Chemical Communications

Detection of atherosclerosis-related hypochlorous acid produced in foam cells with a localized endoplasmic reticulum probe†

Meng-meng Zhang,ab   Yin-Hua Ma,ab   Peng Li,c   Yan Jiaa  and  Ke-Li Han ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS), Dalian 116023, P. R. China
E-mail: klhan@dicp.ac.cn
Fax: +86-411-84675584

b University of the Chinese Academy of Sciences, Beijing 100049, P. R. China

c Shandong University, P. R. China

Abstract

We have synthesized a turn-on fluorescent probe, termed NB4OH, to detect cellular hypochlorite. NB4OH is mainly localized in the endoplasmic reticulum and detects ClO− in foam cells. The fluorescence change of the probe was explained by theoretical calculation as a PET process. The probe holds great promise for application in biomedical research, including atherosclerosis research.

Graphical abstract: Detection of atherosclerosis-related hypochlorous acid produced in foam cells with a localized endoplasmic reticulum probe

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Article information

DOI
https://doi.org/10.1039/D0CC00090F
Article type
Communication
Submitted
06 Jan 2020
Accepted
15 Jan 2020
First published
16 Jan 2020

Chem. Commun., 2020,56, 2610-2613

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Detection of atherosclerosis-related hypochlorous acid produced in foam cells with a localized endoplasmic reticulum probe

M. Zhang, Y. Ma, P. Li, Y. Jia and K. Han, Chem. Commun., 2020, 56, 2610 DOI: 10.1039/D0CC00090F

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