Issue 47, 2019
From the journal:

Journal of Materials Chemistry B

Remodeling the tumor microenvironment to improve drug permeation and antitumor effects by co-delivering quercetin and doxorubicin†

Min Li, ORCID logo a   Xiangfeng Yue,a   Yu Wang,a   Jing Zhang,a   Linwei Kana  and  Ziwei Jing ORCID logo *a  

* Corresponding authors

a Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou 450052, Henan, P. R. China
E-mail: jingziwei1988@126.com

Abstract

The tumor microenvironment (TM) plays a critical role in the progress of tumors. However, the TM remodeling effects of currently available therapies remain largely unexplored in many previous reports. In our study, a hyaluronic acid (HA)-modified zeolitic imidazolate framework (ZIF) was successfully fabricated (HA/ZIF) and employed to load doxorubicin (Dox) and quercetin (Que) simultaneously for cancer therapy. The Que and Dox co-loaded HA/ZIF (HA/ZIF/DQ) showed preferable stability under physiological conditions, pH-responsive drug release in an acidic environment and preferential homing capacity to the CD44 receptor-overexpressed HepG2/ADR cells. More importantly, our results revealed that enhanced anticancer efficacy was achieved through the combination of Que and Dox via the tumor microenvironment remodeling effect of Que to potentiate drug penetration into deep tumor tissues.

Graphical abstract: Remodeling the tumor microenvironment to improve drug permeation and antitumor effects by co-delivering quercetin and doxorubicin

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Article information

DOI
https://doi.org/10.1039/C9TB02131K
Article type
Paper
Submitted
29 Sep 2019
Accepted
23 Oct 2019
First published
09 Nov 2019

J. Mater. Chem. B, 2019,7, 7619-7626

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Remodeling the tumor microenvironment to improve drug permeation and antitumor effects by co-delivering quercetin and doxorubicin

M. Li, X. Yue, Y. Wang, J. Zhang, L. Kan and Z. Jing, J. Mater. Chem. B, 2019, 7, 7619 DOI: 10.1039/C9TB02131K

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