Issue 39, 2019
From the journal:

Journal of Materials Chemistry B

A near-infrared light-responsive nanocomposite for photothermal release of H2S and suppression of cell viability†

Haifeng Li,a   Yu Yao,a   Hui Shi,a   Yanli Lei,b   Yan Huang,a   Kemin Wang, ORCID logo a   Xiaoxiao He*a  and  Jianbo Liu ORCID logo *a  

* Corresponding authors

a A State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, P. R. China
E-mail: xiaoxiaohe@hnu.edu.cn, liujianbo@hnu.edu.cn
Fax: +86 731 88821566
Tel: +86 731 88821566

b School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, China

Abstract

A near-infrared light triggered photothermal H2S-release platform was developed using a combination of photothermal nanoparticles and thermo-labile precursors, and was exploited for synchronous photothermal stimulation and gas release to suppress cell viability. Polyethyleneimine-dithiocarbamate as a H2S donor was assembled on reduced graphene oxide (rGO) nanosheets by electrostatic adsorption. In the nanocomposites, rGO nanosheets converted near-infrared light into thermal energy and activated the H2S donor to produce H2S. Synchronous photothermal stimulation and H2S gas release resulted in effective killing of cancer cells. This work presents an effective method that suppresses the growth of tumour cells and leads to an improved anti-cell proliferation outcome. Near-infrared light-triggered photothermal stimulation, in combination with H2S gas generation, may offer an effective strategy to further develop a cancer synergistic treatment platform.

Graphical abstract: A near-infrared light-responsive nanocomposite for photothermal release of H2S and suppression of cell viability

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Article information

DOI
https://doi.org/10.1039/C9TB01611B
Article type
Paper
Submitted
01 Aug 2019
Accepted
09 Sep 2019
First published
10 Sep 2019

J. Mater. Chem. B, 2019,7, 5992-5997

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A near-infrared light-responsive nanocomposite for photothermal release of H2S and suppression of cell viability

H. Li, Y. Yao, H. Shi, Y. Lei, Y. Huang, K. Wang, X. He and J. Liu, J. Mater. Chem. B, 2019, 7, 5992 DOI: 10.1039/C9TB01611B

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