Glucose-functionalized near-infrared Ag2Se quantum dots with renal excretion ability for long-term in vivo tumor imaging

Xiao-Lei Ge; Biao Huang; Zhi-Ling Zhang; Xiaolan Liu; Man He; Zili Yu; Bin Hu; Ran Cui; Xing-Jie Liang; Dai-Wen Pang

doi:10.1039/C9TB01112A

Glucose-functionalized near-infrared Ag₂Se quantum dots with renal excretion ability for long-term in vivo tumor imaging†

Xiao-Lei Ge,‡^a Biao Huang,‡^a Zhi-Ling Zhang,

^a Xiaolan Liu,^a Man He,

^a Zili Yu,^b Bin Hu,

^a Ran Cui,

*^a Xing-Jie Liang

*^c and Dai-Wen Pang

^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
E-mail: cuiran@whu.edu.cn

^b Key Laboratory of Oral Biomedicine (Ministry of Education) and Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, P. R. China

^c CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, P. R. China
E-mail: liangxj@nanoctr.cn

Abstract

Non-toxic and long-term fluorescent probes for tumor imaging are in urgent need for non-invasively obtaining information about tumor genesis and metastasis in vivo. Here, we present a biocompatible near-infrared fluorescent probe for in vivo long-term imaging of tumor by modifying glucose (Glc), which experiences high uptake in cancer cells, on the surface of near-infrared Ag₂Se quantum dots (NIR Ag₂Se QDs). The fluorescence of glucose-functionalized Ag₂Se QDs (Glc-Ag₂Se QDs) from the targeted tumor can be observed in vivo for at least 7 days. In addition, this probe could be excreted through kidneys and the renal excretion ability is favorable for in vivo imaging applications. Moreover, Glc-Ag₂Se QDs could be used for tumor targeted imaging of not only human breast cancer cells (MCF-7), but also SW1990 pancreatic cancer cells since glucose is highly taken up in almost all kinds of tumors. Glc-Ag₂Se QDs could be a promising general tool for in vivo long-term observation of tumor evolution.

Journal of Materials Chemistry B

Glucose-functionalized near-infrared Ag₂Se quantum dots with renal excretion ability for long-term in vivo tumor imaging†

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Glucose-functionalized near-infrared Ag₂Se quantum dots with renal excretion ability for long-term in vivo tumor imaging

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Journal of Materials Chemistry B