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Optimized synthesis of luminescent silica nanoparticles by a direct micelle-assisted method

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Abstract

Silica nanoparticles (NPs) are versatile nanomaterials, which are safe with respect to biomedical applications, and therefore are highly investigated. The advantages of NPs include their ease of preparation, inexpensive starting materials and the possibility of functionalization or loading with various doping agents. However, the solubility of the doping agent(s) imposes constraints on the choice of the reaction system and hence limits the range of molecules that can be included in the interior of NPs. To overcome this problem, herein, we improved the current state of the art synthetic strategy based on Pluronic F127 by enabling the synthesis in the presence of large amounts of organic solvents. The new method enables the preparation of nanoparticles doped with large amounts of water-insoluble doping agents. To illustrate the applicability of the technology, we successfully incorporated a range of phosphorescent metalloporphyrins into the interior of NPs. The resulting phosphorescent nanoparticles may exhibit potential for biological oxygen sensing.

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Author information

Authors and Affiliations

  1. Department of Chemistry “Giacomo Ciamician”, University of Bologna, Via Selmi 2, 40126, Bologna, Italy

    Benedetta DelSecco, Damiano Genovese, Nelsi Zaccheroni, Enrico Rampazzo & Luca Prodi

  2. Departments of Biochemistry and Biophysics and of Chemistry, University of Pennsylvania, 19104, Philadelphia, PA, USA

    Luca Ravotto, Tatiana V. Esipova & Sergei A. Vinogradov

Authors
  1. Benedetta DelSecco
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  2. Luca Ravotto
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  3. Tatiana V. Esipova
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  4. Sergei A. Vinogradov
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  5. Damiano Genovese
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  6. Nelsi Zaccheroni
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  7. Enrico Rampazzo
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  8. Luca Prodi
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Corresponding author

Correspondence to Sergei A. Vinogradov.

Additional information

Electronic supplementary information (ESI) available: Details of experimental procedures, Dynamic Light Scattering of micelle and nanoparticles suspension, TEM images and photophysical characterization. See DOI: 10.1039/c9pp00047j

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DelSecco, B., Ravotto, L., Esipova, T.V. et al. Optimized synthesis of luminescent silica nanoparticles by a direct micelle-assisted method. Photochem Photobiol Sci 18, 2142–2149 (2019). https://doi.org/10.1039/c9pp00047j

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  • DOI: https://doi.org/10.1039/c9pp00047j

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