Issue 12, 2019

Telescoped synthesis of C3-functionalized (E)-arylamidines using Ugi–Mumm and regiospecific quinazolinone rearrangements

Abstract

An efficient four-step, six-transformation protocol was developed to afford bioactive N-alkyl- or N-arylamide (E)-arylamidines featuring strategic amidine C3 modifications which were inaccessible or low yielding by previous methods. This synthetic approach, exemplified with 24 amidines and requiring only a single purification, highlights a multicomponent Ugi–Mumm rearrangement to afford highly diversified quinazolinones which undergo regiospecific rearrangement to afford new amidines. The method extensively broadens the structural scope of this new class of trisubstituted amidines and demonstrates the tolerance of regional C3 amidine steric bulk, visualized with X-ray crystallographic analysis.

Graphical abstract: Telescoped synthesis of C3-functionalized (E)-arylamidines using Ugi–Mumm and regiospecific quinazolinone rearrangements

Supplementary files

Article information

Article type
Paper
Submitted
10 Jan 2019
Accepted
29 Jan 2019
First published
07 Feb 2019

Org. Biomol. Chem., 2019,17, 3118-3128

Telescoped synthesis of C3-functionalized (E)-arylamidines using Ugi–Mumm and regiospecific quinazolinone rearrangements

V. A. Jaffett, A. Nerurkar, X. Cao, I. A. Guzei and J. E. Golden, Org. Biomol. Chem., 2019, 17, 3118 DOI: 10.1039/C9OB00073A

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