Issue 6, 2020
From the journal:

Nanoscale

Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide†

Wenjie Zhang,a   Reza Taheri-Ledari,b   Zoleikha Hajizadeh,b   Ehsan Zolfaghari,b   Mohammad Reza Ahghari,b   Ali Maleki, ORCID logo *b   Michael R. Hamblin ORCID logo *cde  and  Ye Tian*f  

* Corresponding authors

a Department of Nuclear Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu 610041, Sichuan Province, P.R. China

b Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran
E-mail: maleki@iust.ac.ir

c Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA

d Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA
E-mail: hamblin@helix.mgh.harvard.edu

e Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa

f State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd section of South Renmin Road, Chengdu 610041, P.R. China
E-mail: tianye@scu.edu.cn

Abstract

We describe a novel antibiotic delivery system based on magnetic nanoparticles (NPs) conjugated to a cell-penetrating peptide (CPP). Silica-coated iron oxide NPs were produced via a co-deposition method, and coated by a polyvinyl alcohol (PVA) polymeric network via physicochemical binding. Vancomycin (VAN) was then entrapped into this PVA network. A hexapeptide sequence Gly-Ala-Phe-Pro-His-Arg, was synthesized in the solid phase and then conjugated onto the surface of the magnetic NPs. The drug ratio incorporation into the carrier system and drug release were monitored through precise analysis. Confocal microscopy showed that the NPs could be internalized into Staphylococcus aureus and Escherichia coli bacterial cells. The antimicrobial effects of VAN were significantly enhanced by this system with a low dosage of VAN. Advantages include rapid targeted-drug delivery process, drug dose reduction, and equal effects on both Gram-positive and Gram-negative bacteria.

Graphical abstract: Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide

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Article information

DOI
https://doi.org/10.1039/C9NR09687F
Article type
Paper
Submitted
13 Nov 2019
Accepted
25 Jan 2020
First published
27 Jan 2020

Nanoscale, 2020,12, 3855-3870

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Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide

W. Zhang, R. Taheri-Ledari, Z. Hajizadeh, E. Zolfaghari, M. R. Ahghari, A. Maleki, M. R. Hamblin and Y. Tian, Nanoscale, 2020, 12, 3855 DOI: 10.1039/C9NR09687F

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