Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

Musa M. Musa; Frank Hollmann; Francesco G. Mutti

doi:10.1039/C9CY01539F

Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

Musa M. Musa,

*^a Frank Hollmann

*^b and Francesco G. Mutti

*^c

Author affiliations

* Corresponding authors

^a Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Kingdom of Saudi Arabia
E-mail: musam@kfupm.edu.sa

^b Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629HZ Delft, The Netherlands
E-mail: f.hollmann@tudelft.nl

^c Van't Hoff Institute for Molecular Sciences, HIMS-Biocat, University of Amsterdam, Science Park 904, Amsterdam, The Netherlands
E-mail: f.mutti@uva.nl

Abstract

Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods.

This article is part of the themed collection: 2019 Catalysis Science & Technology HOT Articles

Article information

https://doi.org/10.1039/C9CY01539F

Article type

Minireview

Submitted

01 Aug 2019

Accepted

30 Aug 2019

First published

03 Sep 2019

This article is Open Access

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Catal. Sci. Technol., 2019,9, 5487-5503

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Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

M. M. Musa, F. Hollmann and F. G. Mutti, Catal. Sci. Technol., 2019, 9, 5487 DOI: 10.1039/C9CY01539F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

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