Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo

Min Li; Chuanfeng Wang; Ting Wang; Mengting Fan; Ning Wang; Danying Ma; Ting Hu; Xiaoyan Cui

doi:10.1039/C9CC09666C

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo†

Min Li,‡^a Chuanfeng Wang,‡^a Ting Wang,

*^b Mengting Fan,^a Ning Wang,^a Danying Ma,^a Ting Hu^a and Xiaoyan Cui

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, P. R. China
E-mail: xycui@chem.ecnu.edu.cn

^b College of Pharmacy, Second Military Medical University, Shanghai, P. R. China

Abstract

A group of asymmetric Si-rhodamine scaffolds was designed for protease-activated NIR probes. Dual pH-inertia for both spirocyclized fluorescent probes and fluorescent products of zwitterions form over a wide range of pH (4.0–11.0). Leucine aminopeptidase (LAP) and γ-glutamyl transpeptidase (GGT) were monitored by fluorescent imaging in vivo.

Download options Please wait...

Supplementary files

Supplementary information PDF (2420K)

Article information

DOI: https://doi.org/10.1039/C9CC09666C
Article type: Communication
Submitted: 12 Dec 2019
Accepted: 14 Jan 2020
First published: 16 Jan 2020

Download Citation

Chem. Commun., 2020,56, 2455-2458

Permissions

Request permissions

Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo

M. Li, C. Wang, T. Wang, M. Fan, N. Wang, D. Ma, T. Hu and X. Cui, Chem. Commun., 2020, 56, 2455 DOI: 10.1039/C9CC09666C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Asymmetric Si-rhodamine scaffolds: rational design of pH-durable protease-activated NIR probes in vivo

Social activity

Search articles by author

Spotlight

Advertisements