Polymyxin derivatives as broad-spectrum antibiotic agents

Ma Su; Minghui Wang; Yuzhu Hong; Alekhya Nimmagadda; Ning Shen; Yan Shi; Ruixuan Gao; En Zhang; Chuanhai Cao; Jianfeng Cai

doi:10.1039/C9CC06908A

Polymyxin derivatives as broad-spectrum antibiotic agents†

Ma Su,^a Minghui Wang,^a Yuzhu Hong,^b Alekhya Nimmagadda,^a Ning Shen,^b Yan Shi,^a Ruixuan Gao,^a En Zhang,^ac Chuanhai Cao*^b and Jianfeng Cai

*^a

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^a Department of Chemistry, University of South Florida, Tampa, FL 33620, USA
E-mail: jianfengcai@usf.edu

^b College of Pharmacy, University of South Florida, Tampa, FL 33620, USA
E-mail: ccao@health.usf.edu

^c School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China

Abstract

We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.

Chemical Communications

Polymyxin derivatives as broad-spectrum antibiotic agents†

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Polymyxin derivatives as broad-spectrum antibiotic agents

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