Issue 67, 2019
From the journal:

Chemical Communications

Cu-Catalyzed cyanoalkylation of electron-deficient alkenes with unactivated alkyl bromides†

Chao Wang,‡a   Qinyu Shang,‡a   Rupeng Qi,a   Hongli Chai,a   Hongying Wang,a   Mengzhun Guoa  and  Zhaoqing Xu ORCID logo *a  

* Corresponding authors

a The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, Lanzhou University, Lanzhou, Gansu 730000, China
E-mail: zqxu@lzu.edu.cn

Abstract

We here report the photoinduced Cu-catalyzed cyanoalkylation of electron-deficient alkenes by using alkyl bromides as alkylation reagents. In the reactions, 1°, 2°, and 3° unactivated alkyl bromides with various sensitive functional groups were well tolerated with good yields. Notably, terminal and internal alkenes, as well as alkene-containing peptides, were all tolerated well.

Graphical abstract: Cu-Catalyzed cyanoalkylation of electron-deficient alkenes with unactivated alkyl bromides

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Article information

DOI
https://doi.org/10.1039/C9CC04432A
Article type
Communication
Submitted
10 Jun 2019
Accepted
25 Jul 2019
First published
01 Aug 2019

Chem. Commun., 2019,55, 9991-9994

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Cu-Catalyzed cyanoalkylation of electron-deficient alkenes with unactivated alkyl bromides

C. Wang, Q. Shang, R. Qi, H. Chai, H. Wang, M. Guo and Z. Xu, Chem. Commun., 2019, 55, 9991 DOI: 10.1039/C9CC04432A

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