Issue 63, 2019
From the journal:

Chemical Communications

A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation†

Wangteng Wu, ORCID logo ‡ab   Qida Hu, ORCID logo ‡a   Meng Wang,a   Shiyi Shao,a   Xinyu Zhao,a   Hongzhen Bai,b   Junming Huang,a   Guping Tang ORCID logo *b  and  Tingbo Liang*acd  

* Corresponding authors

a Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
E-mail: liangtingbo@zju.edu.cn

b Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Hangzhou 310028, China
E-mail: tangguping@zju.edu.cn

c The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou 310003, China

d Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou 310003, China

Abstract

We developed a biodegradable, oncosensitive, megamer-based delivery system for miRNA therapy. The miRNA nanotherapeutics, activatable by stepwise stimulation of acidity and reduction mimicking tumor microenvironment, efficiently improve liver-specific miR-122 expression, increasing the possibility of translational application of miR-122 therapy against liver cancer.

Graphical abstract: A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation

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Article information

DOI
https://doi.org/10.1039/C9CC03846A
Article type
Communication
Submitted
17 May 2019
Accepted
06 Jul 2019
First published
08 Jul 2019

Chem. Commun., 2019,55, 9363-9366

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A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation

W. Wu, Q. Hu, M. Wang, S. Shao, X. Zhao, H. Bai, J. Huang, G. Tang and T. Liang, Chem. Commun., 2019, 55, 9363 DOI: 10.1039/C9CC03846A

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