Issue 69, 2019
From the journal:

Chemical Communications

A nanoparticle enabled focused ultrasound-stimulated magnetic resonance imaging spotlight†

Tian Deng, ORCID logo ‡ab   Le Zhang, ORCID logo ‡c   Holden H. Wu ORCID logo *cd  and  Jeffrey I. Zink ORCID logo *ab  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, USA
E-mail: zink@chem.ucla.edu

b California Nano Systems Institute (CNSI), University of California Los Angeles, Los Angeles, California 90095, USA

c Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
E-mail: HoldenWu@mednet.ucla.edu

d Department of Bioengineering, University of California Los Angeles, Los Angeles, California 90095, USA

Abstract

Periodic high-intensity focused ultrasound modulation of a nanoparticle generates reversible MRI T1 relaxivity changes at the 1.5 mm3 focal point causing periodic T1-weighted signal changes. Fourier analysis extracts signal changes at the modulation frequency, and a modulation enhancement map spotlights the precise region of interest by increasing contrast almost 100-fold.

Graphical abstract: A nanoparticle enabled focused ultrasound-stimulated magnetic resonance imaging spotlight

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Article information

DOI
https://doi.org/10.1039/C9CC03701B
Article type
Communication
Submitted
14 May 2019
Accepted
31 Jul 2019
First published
02 Aug 2019

Chem. Commun., 2019,55, 10261-10264

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A nanoparticle enabled focused ultrasound-stimulated magnetic resonance imaging spotlight

T. Deng, L. Zhang, H. H. Wu and J. I. Zink, Chem. Commun., 2019, 55, 10261 DOI: 10.1039/C9CC03701B

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