Issue 52, 2019
From the journal:

Chemical Communications

Stem–loop clutch probes for sequence-specific dsDNA analysis with improved single-mismatch selectivity†

Xing Lu,a   Guobao Zhou, ORCID logo *a   Yixia Lua  and  Lei Li*a  

* Corresponding authors

a College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China
E-mail: lei.li@mail.zjxu.edu.cn, gbzhou@mail.zjxu.edu.cn

Abstract

A stem–loop clutch probe (SLCP)-based strategy has been explored to guide sequence-specific double stranded DNA (dsDNA) analysis with enhanced single-base mismatch selectivity. This assay method can also modulate the dynamic range by employing natural processes relying on distal-site mutation inhibition and allosteric activation.

Graphical abstract: Stem–loop clutch probes for sequence-specific dsDNA analysis with improved single-mismatch selectivity

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Article information

DOI
https://doi.org/10.1039/C9CC03137E
Article type
Communication
Submitted
23 Apr 2019
Accepted
03 Jun 2019
First published
04 Jun 2019

Chem. Commun., 2019,55, 7514-7517

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Stem–loop clutch probes for sequence-specific dsDNA analysis with improved single-mismatch selectivity

X. Lu, G. Zhou, Y. Lu and L. Li, Chem. Commun., 2019, 55, 7514 DOI: 10.1039/C9CC03137E

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