A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil

Xin Dai; Xueying Zhou; Chunyan Liao; Yongchao Yao; Yunlong Yu; Shiyong Zhang

doi:10.1039/C9CC03012C

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A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil†

Xin Dai,^ab Xueying Zhou,^a Chunyan Liao,^a Yongchao Yao,

^a Yunlong Yu^a and Shiyong Zhang

*^a

Author affiliations

* Corresponding authors

^a National Engineering Research Centre for Biomaterials, and College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China
E-mail: szhang@scu.edu.cn

^b Zunyi Medical and Pharmaceutical College, Pingan Road, Xinpu District, Zunyi 56300, China

Abstract

A nanodrug that can effectively combat cisplatin-resistant A549/CDDP cells was developed by protecting cisplatin from glutathione (GSH) detoxification trough a host–guest interaction between cisplatin and p-sulfonatocalix[4]arene. The enzymatic activity of glutathione S-transferases (GSTs) was also regulated by loaded 5-fluorouracil (5-FU).

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Article information

DOI: https://doi.org/10.1039/C9CC03012C
Article type: Communication
Submitted: 17 Apr 2019
Accepted: 26 May 2019
First published: 27 May 2019

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Chem. Commun., 2019,55, 7199-7202

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A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil

X. Dai, X. Zhou, C. Liao, Y. Yao, Y. Yu and S. Zhang, Chem. Commun., 2019, 55, 7199 DOI: 10.1039/C9CC03012C

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Chemical Communications

A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil†

Abstract

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A nanodrug to combat cisplatin-resistance by protecting cisplatin with p-sulfonatocalix[4]arene and regulating glutathione S-transferases with loaded 5-fluorouracil

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