Site-selective C(sp3)–H amination of thioamide with anthranils under Cp*CoIII catalysis

Rui-Hua Liu; Qi-Chao Shan; Xu-Hong Hu; Teck-Peng Loh

doi:10.1039/C9CC01715A

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Site-selective C(sp³)–H amination of thioamide with anthranils under Cp*Co^III catalysis†

Rui-Hua Liu,^a Qi-Chao Shan,^a Xu-Hong Hu

*^a and Teck-Peng Loh

*^ab

Author affiliations

* Corresponding authors

^a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China
E-mail: ias_xhhu@njtech.edu.cn

^b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
E-mail: teckpeng@ntu.edu.sg

Abstract

Synthetically versatile anthranils as a bifunctional amino source have been employed for the first time to enable direct amination on unactivated C(sp³)–H bonds of thioamides under Cp*Co^III catalysis. The excellent site-selectivity on primary C(sp³)–H bonds is observed for a diverse array of thioamides with high functional group tolerance. Further applicability of the products is also highlighted through a series of interesting synthetic elaborations.

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Article information

DOI: https://doi.org/10.1039/C9CC01715A
Article type: Communication
Submitted: 04 Mar 2019
Accepted: 16 Apr 2019
First published: 22 Apr 2019

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Chem. Commun., 2019,55, 5519-5522

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Site-selective C(sp³)–H amination of thioamide with anthranils under Cp*Co^III catalysis

R. Liu, Q. Shan, X. Hu and T. Loh, Chem. Commun., 2019, 55, 5519 DOI: 10.1039/C9CC01715A

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