Issue 29, 2019
From the journal:

Chemical Communications

Autophagy inducing cyclic peptides constructed by methionine alkylation†

Xuan Qin,‡a   Xiaodong Shi,‡a   Licheng Tu,a   Yue Ma,a   Ziyuan Zhou,a   Rongtong Zhao,a   Meimiao Zhan,a   Feng Yin ORCID logo *a  and  Zigang Li ORCID logo *a  

* Corresponding authors

a State Key laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, P. R. China
E-mail: yinfeng@pkusz.edu.cn, lizg@pkusz.edu.cn

Abstract

Peptides that induced autophagy at micromolar concentrations with improved proteolytic resistance properties were generated using the facile methionine bis-alkylation method. Notably, a short bicyclic peptide 7f was proven to be the most potent one among the designed peptides in regards to autophagy inducing activity. This study facilitated the development of a peptide-based autophagy inducer and demonstrated the potential applications of the methionine alkylation-based macrocyclization method for the diversity-oriented generation of peptide-based autophagy inducers.

Graphical abstract: Autophagy inducing cyclic peptides constructed by methionine alkylation

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Article information

DOI
https://doi.org/10.1039/C9CC01027K
Article type
Communication
Submitted
04 Feb 2019
Accepted
05 Mar 2019
First published
05 Mar 2019

Chem. Commun., 2019,55, 4198-4201

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Autophagy inducing cyclic peptides constructed by methionine alkylation

X. Qin, X. Shi, L. Tu, Y. Ma, Z. Zhou, R. Zhao, M. Zhan, F. Yin and Z. Li, Chem. Commun., 2019, 55, 4198 DOI: 10.1039/C9CC01027K

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