Issue 24, 2019
From the journal:

Analyst

The construction of DNAzyme-based logic gates for amplified microRNA detection and cancer recognition†

Lingyu Wu,a   Min Pan,a   Yuqi Chen,a   Haiyan Huang,a   Xiaoe Zhang,a   Fuan Wang ORCID logo *a  and  Xiang Zhou ORCID logo *a  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: xzhou@whu.edu.cn, fuanwang@whu.edu.cn
Fax: (+) 86-27-68756663
Tel: (+) 86-27-68756663

Abstract

Benefiting from the simple DNAzyme and a duplex-specific nuclease, a series of microRNA-stimulated DNAzyme logic gates were rationally assembled for the highly accurate detection of multiple low-abundant microRNA biomarkers that correspond to the specific aberrant microRNA expression patterns of cancer tissues, thus showing a great potential in early diagnosis.

Graphical abstract: The construction of DNAzyme-based logic gates for amplified microRNA detection and cancer recognition

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Article information

DOI
https://doi.org/10.1039/C9AN01977D
Article type
Paper
Submitted
04 Oct 2019
Accepted
21 Oct 2019
First published
29 Oct 2019

Analyst, 2019,144, 7278-7282

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The construction of DNAzyme-based logic gates for amplified microRNA detection and cancer recognition

L. Wu, M. Pan, Y. Chen, H. Huang, X. Zhang, F. Wang and X. Zhou, Analyst, 2019, 144, 7278 DOI: 10.1039/C9AN01977D

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