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Combination of PDT photosensitizers with NO photodononors

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Abstract

Combination of photodynamic therapy (PDT) with other treatment modalities is emerging as one of the most suitable strategies to increase the effectiveness of therapeutic action on cancer and bacterial diseases and to minimize side effects. This approach aims at exploiting the additive/synergistic effects arising from multiple therapeutic species acting on different mechanistic pathways. The coupling of PDT with photocontrolled release of nitric oxide (NO) through the appropriate assembly of PDT photosensitizers (PSs) and NO photodonors (NOPDs) may open up intriguing avenues towards new and still underexplored multimodal therapies not based on “conventional” drugs but entirely controlled by light stimuli. In this contribution, we present an overview of the most recent advances in this field, illustrating several strategies to assemble PSs and NOPDs allowing them to operate independently without reciprocal interferences and describing the potential applications with particular emphasis on their impact in anticancer and antibacterial research.

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Acknowledgments

We are grateful to all those researchers who have been contributing to this exciting subject and whose names are listed in the reference list. We also thank the referees for their constructive comments that helped improve the quality of the manuscript. Part of the research described in this paper has been supported by the AIRC (Project IG-12834 and Project IG-19859) and the Marie Curie Program #608407 CYCLON HIT (FP7-PEOPLE-ITN-2013).

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  1. Department of Drug Sciences, Laboratory of Photochemistry, Viale Andrea Doria 6, I-95125, Catania, Italy

    Aurore Fraix & Salvatore Sortino

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Correspondence to Salvatore Sortino.

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Fraix, A., Sortino, S. Combination of PDT photosensitizers with NO photodononors. Photochem Photobiol Sci 17, 1709–1727 (2018). https://doi.org/10.1039/c8pp00272j

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