Issue 47, 2018

A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes

Abstract

A unique gold(I)-catalyzed 5-endo-dig cyclization/aerobic oxidation cascade strategy from 1,5-enyne substrates with molecular oxygen as the oxidant to yield the indenone was described. The reaction mechanism was studied by heavy atom labelling and some related experiments. This method was applied to the formal total synthesis of isoprekinamycin.

Graphical abstract: A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes

Supplementary files

Article information

Article type
Communication
Submitted
17 Oct 2018
Accepted
14 Nov 2018
First published
15 Nov 2018

Org. Biomol. Chem., 2018,16, 9147-9151

A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes

J. Guo, X. Peng, X. Wang, F. Xie, X. Zhang, G. Liang, Z. Sun, Y. Liu, M. Cheng and Y. Liu, Org. Biomol. Chem., 2018, 16, 9147 DOI: 10.1039/C8OB02582G

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