An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo

Anna Wang; Ling Yin; Lei He; Huawei Xia; Fei Chen; Meng Zhao; Jianan Ding; Haibin Shi

doi:10.1039/C8NR05061A

An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo†

Anna Wang,‡^a Ling Yin,‡^bc Lei He,^a Huawei Xia,^a Fei Chen,^d Meng Zhao,^a Jianan Ding^a and Haibin Shi

*^a

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* Corresponding authors

^a State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, 199 Renai Road, Suzhou 215123, China
E-mail: hbshi@suda.edu.cn

^b Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, P. R. China

^c Department of Chemistry and Chemical Engineering, Jining University, Qufu 273155, China

^d Department of Nuclear Medicine, Nanjing Medical University, Affiliated Wuxi People's Hospital, Wuxi, Jiangsu 214023, China

Abstract

Computed tomography (CT) is one of the most frequently used diagnostic imaging modalities in clinics. However, the fast clearance of CT contrast agents through the kidney and short circulation time severely restrict their in vivo applications. Herein, taking advantage of the biocompatible CBT condensation reaction, we rationally designed and synthesized a new smart acidic pH/glutathione (GSH) dual-stimuli responsive nanoprobe (1) which can intermolecularly undergo condensation and form a nanoparticle assembly (I-NPs) in the tumour microenvironment. In vivo CT imaging results indicated that probe 1 could be successfully applied for enhanced CT imaging of tumours in nude mice with a low dose of 21.79 mg I per kg body weight, which may offer a promising tool for precise tumor diagnosis.

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DOI: https://doi.org/10.1039/C8NR05061A
Article type: Communication
Submitted: 22 Jun 2018
Accepted: 21 Oct 2018
First published: 22 Oct 2018

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Nanoscale, 2018,10, 20126-20130

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An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo

A. Wang, L. Yin, L. He, H. Xia, F. Chen, M. Zhao, J. Ding and H. Shi, Nanoscale, 2018, 10, 20126 DOI: 10.1039/C8NR05061A

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An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo†

Abstract

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An acidic pH/reduction dual-stimuli responsive nanoprobe for enhanced CT imaging of tumours in vivo

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