Issue 5, 2019
From the journal:

Food & Function

Effects of omega-3 polyunsaturated fatty acids on steroidogenesis and cellular development in PCOS rats

Xusong Hu,†ab   Xuechun Weng,†b   Ye Tian,†b   Chengtao Wang,†a   Yanzhou Yang,c   Kaili Xub  and  Cheng Zhang ORCID logo *ab  

* Corresponding authors

a Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, Peoples’ Republic of China
E-mail: zhch8012@163.com

b College of Life Science, Capital Normal University, Beijing 100048, Peoples’ Republic of China

c Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Ningxia 750004, Peoples’ Republic of China

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, which is characterized by hyperandrogenism. Polyunsaturated fatty acids (PUFAs) are necessary for the body's metabolism, growth and development. Despite the well-known benefits of omega-3 polyunsaturated fatty acid supplementation on the modulation of PCOS ovarian function, relatively little is known about the precise regulation mechanism. The objective of this study was to determine the cellular and molecular mechanisms by which omega-3 regulates CYP51 expression and steroid biosynthesis during follicle growth in PCOS. The results indicated that the CYP51 expression was up-regulated in granulosa cells by omega-3. Moreover, the knockdown of CYP51 blocked omega-3 induced estradiol (E2) and progesterone (P4) synthesis as well as cellular viability and proliferation. These changes were accompanied by the up-regulation of the p-Akt level. Furthermore, the PI3K/Akt pathway was required for the regulation of CYP51 expression, steroidogenesis and cell development by omega-3 in PCOS granulosa cells. Our data demonstrate that omega-3 potentiates the cellular development and steroid biosynthesis via CYP51 up-regulation in PCOS, which are mediated through the activation of the PI3K/Akt pathway.

Graphical abstract: Effects of omega-3 polyunsaturated fatty acids on steroidogenesis and cellular development in PCOS rats

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Article information

DOI
https://doi.org/10.1039/C8FO02319K
Article type
Paper
Submitted
26 Nov 2018
Accepted
27 Mar 2019
First published
28 Mar 2019

Food Funct., 2019,10, 2504-2514

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Effects of omega-3 polyunsaturated fatty acids on steroidogenesis and cellular development in PCOS rats

X. Hu, X. Weng, Y. Tian, C. Wang, Y. Yang, K. Xu and C. Zhang, Food Funct., 2019, 10, 2504 DOI: 10.1039/C8FO02319K

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