Issue 16, 2019
From the journal:

Chemical Communications

Catalyst-controlled cascade synthesis of bridged bicyclic tetrahydrobenz[b]azepine-4-ones†

Michelle A. Kroc,a   Maciej Markiewicz,a   Wiktoria H. Pace,a   Donald J. Wink ORCID logo a  and  Laura L. Anderson ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor St. MC 111, Chicago, IL 60607, USA
E-mail: lauralin@uic.edu

Abstract

A catalyst-controlled cascade reaction has been developed for the synthesis of bridged bicyclic tetrahydrobenz[b]azepin-4-ones from N-arylnitrones and allenes. This method expands the accessible structural diversity of a synthetically challenging heterocyclic scaffold and tunes a catalyst-sensitive process in a new direction.

Graphical abstract: Catalyst-controlled cascade synthesis of bridged bicyclic tetrahydrobenz[b]azepine-4-ones

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Article information

DOI
https://doi.org/10.1039/C8CC10313E
Article type
Communication
Submitted
31 Dec 2018
Accepted
29 Jan 2019
First published
30 Jan 2019

Chem. Commun., 2019,55, 2309-2312

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Catalyst-controlled cascade synthesis of bridged bicyclic tetrahydrobenz[b]azepine-4-ones

M. A. Kroc, M. Markiewicz, W. H. Pace, D. J. Wink and L. L. Anderson, Chem. Commun., 2019, 55, 2309 DOI: 10.1039/C8CC10313E

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