Issue 12, 2019

Copper-catalyzed aminothiolation of terminal alkynes with tunable regioselectivity

Abstract

A simple, mild, and efficient catalytic aminothiolation of terminal alkynes for the synthesis of both 2- and 3-substituted thiazolo[3,2-a]benzimidazoles is established upon catalysis with copper(I), in which complementary regioselectivities could be achieved by using sterically different phenanthroline-based ligands.

Graphical abstract: Copper-catalyzed aminothiolation of terminal alkynes with tunable regioselectivity

Supplementary files

Article information

Article type
Communication
Submitted
16 Nov 2018
Accepted
26 Dec 2018
First published
02 Jan 2019

Chem. Commun., 2019,55, 1813-1816

Author version available

Copper-catalyzed aminothiolation of terminal alkynes with tunable regioselectivity

J. Kuang, Y. Xia, A. Yang, H. Zhang, C. Su and D. Lee, Chem. Commun., 2019, 55, 1813 DOI: 10.1039/C8CC09122F

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