Issue 47, 2018
From the journal:

Chemical Communications

Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates†

Zhengwei Zhou,‡a   Mei Cong,‡b   Mengyao Li,a   Aura Tintaru,c   Jia Li,d   Jianhua Yao,d   Yi Xia ORCID logo *a  and  Ling Peng ORCID logo *b  

* Corresponding authors

a Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, China
E-mail: yixia@cqu.edu.cn

b Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, “Equipe Labellisée Ligue Contre le Cancer”, Marseille 13288, France
E-mail: ling.peng@univ-amu.fr

c Aix-Marseille Université, CNRS, UMR 7273, Institut de Chimie Radicalaire, Marseille, France

d Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

Abstract

Dendrimers possess intriguing “dendritic effects”, which are unique characteristics that stem from the dendrimer generation and size. Here we report a “negative dendritic effect” observed during enzymatic hydrolysis of dendrimer conjugates. Such negative dendritic effects, though rarely reported, may be explored for tailored and generation-dependent drug release.

Graphical abstract: Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates

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Article information

DOI
https://doi.org/10.1039/C8CC01221K
Article type
Communication
Submitted
11 Feb 2018
Accepted
03 Apr 2018
First published
25 May 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 5956-5959

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Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates

Z. Zhou, M. Cong, M. Li, A. Tintaru, J. Li, J. Yao, Y. Xia and L. Peng, Chem. Commun., 2018, 54, 5956 DOI: 10.1039/C8CC01221K

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