Issue 11, 2017
From the journal:

Chemical Science

Magnetic control of cellular processes using biofunctional nanoparticles

Cornelia Monzel, ORCID logo a   Chiara Vicario,a   Jacob Piehler,b   Mathieu Coppeya  and  Maxime Dahan*a  

* Corresponding authors

a Institut Curie, PSL Research University, Laboratoire Physico Chimie, CNRS UMR168, UPMC, F-75005 Paris, France
E-mail: maxime.dahan@curie.fr

b University of Osnabrück, Department of Biology/Chemistry, Division of Biophysics, 49076 Osnabrück, Germany

Abstract

Remote control of cellular functions is a key challenge in biomedical research. Only a few tools are currently capable of manipulating cellular events at distance, at spatial and temporal scales matching their naturally active range. A promising approach, often referred to as ‘magnetogenetics’, is based on the use of magnetic fields, in conjunction with targeted biofunctional magnetic nanoparticles. By triggering molecular stimuli via mechanical, thermal or biochemical perturbations, magnetic actuation constitutes a highly versatile tool with numerous applications in fundamental research as well as exciting prospects in nano- and regenerative medicine. Here, we highlight recent studies, comment on the advancement of magnetic manipulation, and discuss remaining challenges.

Graphical abstract: Magnetic control of cellular processes using biofunctional nanoparticles

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Article information

DOI
https://doi.org/10.1039/C7SC01462G
Article type
Minireview
Submitted
01 Apr 2017
Accepted
07 Aug 2017
First published
09 Aug 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2017,8, 7330-7338

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Magnetic control of cellular processes using biofunctional nanoparticles

C. Monzel, C. Vicario, J. Piehler, M. Coppey and M. Dahan, Chem. Sci., 2017, 8, 7330 DOI: 10.1039/C7SC01462G

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