Issue 55, 2017
From the journal:

RSC Advances

Porous Li-containing biphasic calcium phosphate scaffolds fabricated by three-dimensional plotting for bone repair†

Xiaoheng Guo, ORCID logo ‡ab   Huichang Gao,‡d   Xiao Liu,ab   Jingjing Diao,ac   Xuetao Shi,ab   Naru Zhao*ac  and  Yingjun Wang ORCID logo *ab  

* Corresponding authors

a School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
E-mail: nrzhao@scut.edu.cn, imwangyj@163.com
Tel: +86-20-87114645

b Nation Engineering Research Centre for Tissue Restoration and Reconstruction, Guangzhou 510006, China

c Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China

d School of Medicine, South China University of Technology, Guangzhou 510006, China

Abstract

A well-designed scaffold with accurately controlled structure, pore size as well as interconnection plays a key role in tissue engineering. In this study, porous Li-containing biphasic calcium phosphate scaffolds (Li-BCP) with expected structure were fabricated successfully by 3D plotting technique. The results of scanning electron microscopy (SEM) and micro-CT indicated that scaffolds from 3D plotting possessed an elaborate pore structure, porosity and interconnection. Besides, Li-BCP scaffolds also possessed excellent mechanical strength. Furthermore, in vitro cell experiments confirmed that mouse bone mesenchymal stem cells (mBMSCs) cultured on Li-BCP scaffolds exhibited good adhesion and spreading. Moreover, Li-BCP scaffolds could efficaciously promote the proliferation and osteogenic differentiation of mBMSCs, demonstrating their potential applicability as a candidate for bone repair applications.

Graphical abstract: Porous Li-containing biphasic calcium phosphate scaffolds fabricated by three-dimensional plotting for bone repair

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Article information

DOI
https://doi.org/10.1039/C7RA04155A
Article type
Paper
Submitted
12 Apr 2017
Accepted
30 Jun 2017
First published
10 Jul 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 34508-34516

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Porous Li-containing biphasic calcium phosphate scaffolds fabricated by three-dimensional plotting for bone repair

X. Guo, H. Gao, X. Liu, J. Diao, X. Shi, N. Zhao and Y. Wang, RSC Adv., 2017, 7, 34508 DOI: 10.1039/C7RA04155A

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