Issue 23, 2017
From the journal:

Organic & Biomolecular Chemistry

Oxalic acid as the in situ carbon monoxide generator in palladium-catalyzed hydroxycarbonylation of arylhalides†

Changdong Shao, ORCID logo ab   Ailan Lu,a   Xiaoling Wang,a   Bo Zhou,a   Xiaohong Guan*bc  and  Yanghui Zhang*abd  

* Corresponding authors

a School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, P.R. China
E-mail: zhangyanghui@tongji.edu.cn
Web: http://zhangyhgroup.tongji.edu.cn

b UNEP-Tongji Institute of Environment for Sustainable Development, Tongji University, 1239 Siping Road, Shanghai 200092, P.R. China

c College of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, P. R. China

d Shanghai Key Laboratory of Chemical Assessment and Sustainability, 1239 Siping Road, Shanghai 200092, P.R. China

Abstract

An efficient palladium-catalyzed hydroxycarbonylation reaction of arylhalides using oxalic acid as a CO source has been developed. The reaction features high safety, low catalyst loading, and a broad substrate scope, and provides a safe and tractable approach to access a variety of aromatic carboxylic acid compounds. Mechanistic studies revealed the decomposition pattern of oxalic acid.

Graphical abstract: Oxalic acid as the in situ carbon monoxide generator in palladium-catalyzed hydroxycarbonylation of arylhalides

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Article information

DOI
https://doi.org/10.1039/C7OB01052D
Article type
Paper
Submitted
30 Apr 2017
Accepted
19 May 2017
First published
22 May 2017

Org. Biomol. Chem., 2017,15, 5033-5040

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Oxalic acid as the in situ carbon monoxide generator in palladium-catalyzed hydroxycarbonylation of arylhalides

C. Shao, A. Lu, X. Wang, B. Zhou, X. Guan and Y. Zhang, Org. Biomol. Chem., 2017, 15, 5033 DOI: 10.1039/C7OB01052D

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