A highly selective and sensitive fluorescent probe for Cu2+ based on a novel naphthalimide–rhodamine platform and its application in live cell imaging

Chang Liu; Xiaojie Jiao; Song He; Liancheng Zhao; Xianshun Zeng

doi:10.1039/C7OB00538E

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A highly selective and sensitive fluorescent probe for Cu²⁺ based on a novel naphthalimide–rhodamine platform and its application in live cell imaging†

Chang Liu,^a Xiaojie Jiao,^b Song He,^b Liancheng Zhao^ab and Xianshun Zeng

*^ab

Author affiliations

* Corresponding authors

^a School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China
E-mail: xshzeng@tjut.edu.cn
Fax: +86-22-60215226
Tel: +86-22-60216748

^b Tianjin Key Laboratory for Photoelectric Materials and Devices, Tianjin University of Technology, Tianjin 300384, China

Abstract

Copper plays important roles in a variety of fundamental physiological processes. At the cell organelle level, aberrant copper homeostasis in lysosomes can lead to various serious diseases. Herein, a bifluorophore-based, lysosome-targetable Cu²⁺-selective ratiometric fluorescent probe (V) has been synthesized by reasonable design. The probe V shows high selectivity toward Cu²⁺ ions over other cations and exhibits high sensitivity (1.45 nM) for the detection of Cu²⁺ ions. Meanwhile, the probe is cell permeable and suitable for ratiometric visualization of lysosomal Cu²⁺ in the living cell.

Download options Please wait...

Supplementary files

Supplementary information PDF (2371K)

Article information

DOI: https://doi.org/10.1039/C7OB00538E
Article type: Paper
Submitted: 03 Mar 2017
Accepted: 11 Apr 2017
First published: 12 Apr 2017

Download Citation

Org. Biomol. Chem., 2017,15, 3947-3954

Permissions

Request permissions

A highly selective and sensitive fluorescent probe for Cu²⁺ based on a novel naphthalimide–rhodamine platform and its application in live cell imaging

C. Liu, X. Jiao, S. He, L. Zhao and X. Zeng, Org. Biomol. Chem., 2017, 15, 3947 DOI: 10.1039/C7OB00538E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry